Damage confirmed
ثبت نشده
چکیده
Are better drugs just a click away? Drugs that show promise in preclinical models often fail in the clinic, in part because of limited information on drug localization within cells and across tissues. In a proof-of-concept study, Tyler et al. applied click chemistry methods to study the localization of bromodomain inhibitors. These are cancer drugs that alter chromatin structure and gene expression. Clickable derivatives of the drugs localized within chromatin and showed that the drugs exhibit distinct modes of binding at responsive and unresponsive genes. In a mouse leukemia model, the click-probes revealed that the drugs accumulate to different extents in the spleen and bone marrow, which are two tissue sources of leukemic cells. —PAK Science, this issue p. 1397
منابع مشابه
A Nonlinear Creep-damage Constitutive Model of Mudstone Based on the Fractional Calculus Theory
During the flood development in an oil field, the creep characteristic of mudstone is one of the important factors causing casing damage. In this study, based on the theory of fractional order differential and taking into account the creep damage evolution rules, a fractional nonlinear creep-damage model is proposed to reflect the instantaneous deformation in loading processes and the accelerat...
متن کاملOn the Use of Acoustic Emission and Digital Image Correlation for Welded Joints Damage Characterization
A series of tests have been conducted to investigate fatigue damage characterization in corroded welded steel plates using structural health monitoring (SHM) techniques. Acoustic Emission (AE) is a non-destructive testing (NDT) technique with potential applications for locating and monitoring fatigue cracks in service. In the present work, AE is implemented to characterize damage during crack e...
متن کاملE/m Impedance Health Monitoring of Spot-welded Structural Joints
1 TRACT erimental results obtained during fatigue testing of a lded lap-shear structural-joint specimen are d. In these experiments, the electro-mechanical mpedance technique was used for structural health ing, damage detection, and NDE. The test ns were instrumented with piezo-electric wafer ers, and the base E/M impedance signature was over the relevant frequency range. Fatigue testing lied t...
متن کاملDamage Behavior in Modern Automotive High Strength Dual Phase Steels During Uniaxial Tensile Deformation
In the present research, damage mechanisms during room temperature uniaxial tensile testing of two different modern high strength dual phase steels,DP780 and DP980, were studied. Detailed microstructural characterization of the strained and sectioned samples was performed by scanning electron microscopy (SEM). The results revealed that interface decohesion, especially at the triple junctions of...
متن کاملساخت مقیاس آسیبشناسی سازمانی بر اساس مدل سه شاخگی و بررسی آسیبهای سازمانی در شرکتهای صنایع غذایی
The purpose of this study was to construct an organizational pathology scale and to investigate organizational damage in food industry companies based on the three-branch model. This research is applied study, in terms of its purpose and in terms of research method, it is a mixed type. The statistical population of this study is all employees of Amol Industrial City Food Industries Company. Th...
متن کاملVISCOUS DAMPER PLACEMENT OPTIMIZATION IN CONCRETE STRUCTURES USING COLLIDING BODIES ALGORITHM AND STORY DAMAGE INDEX
Dampers can reduce structural response under dynamic loads. Since dampers are costly, the design of structures equipped with dampers should make their application economically justifiable. Among the effective cost reduction factors is optimal damper placement. Hence, this study intended to find the optimal viscous damper placement using efficient optimization methods. Taking into account the no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017